11/23/2023 0 Comments Arthritis weather calculatorTo identify the most suitable CVD risk calculator in predicting the CAC score, a correlation analysis between the CVD risk score and the CAC score was performed.ĭata of patients who visited single tertiary hospital (Konkuk University Medical Center) between March 2020 and December 2020 were collected. In the present study, we assessed the CVD risk score using different widely used calculators (Framingham risk score, Systemic Coronary Risk Evaluation, Atherosclerotic Cardiovascular Disease risk estimator plus, QRISK3, ERS-RA, Reynolds risk score) in RA patients, and compared these among different RA subgroups based on the CAC score. The present study aimed to find out most suitable CVD risk calculator on prediction of subclinical atherosclerosis of RA patients for the first time. However, the most suitable CVD risk calculator for predicting subclinical atherosclerosis in RA patients has not been determined yet. A study showed that the Framingham risk score significantly correlated with the CAC score in RA patients. Therefore, the recent American and European Cardiology Associations recommend considering evaluation of the CAC score to improve CVD risk assessment. This score could provide additional information in patients with an intermediate risk of CVD, which would aid in deciding preventive therapy in these patients. The CAC score quantifies the severity of atherosclerosis by calculating the area and the density of calcium deposit in the major coronary arteries. ![]() Only low dose radiation (0.7–3 mSv) without contrast enhancement cardiac computed tomography (CT) is required to calculate the CAC score. Ĭoronary artery calcium (CAC) score is a useful method to detect subclinical atherosclerosis in an asymptomatic population. However, RA-specific CVD risk calculators were not found to be superior to other traditional CVD risk calculators used in the general population in predicting CVD in RA patients. Several RA-specific CVD risk calculators, such as Expanded Cardiovascular Risk Prediction Score for RA (ERS-RA) and QRISK have been validated in RA patients. The estimated CVD risk is then multiplied by 1.5 in RA patients. The first step involves estimating the individual risk of CVD with an accurate CVD risk calculator. The European League against Rheumatism (EULAR) taskforce published guidelines for CVD risk management in RA patients. The hazard ratio of CVD was found to be 1.94 in RA patients when compared to that in the general population. The leading cause of mortality in RA patients is cardiovascular disease (CVD). ![]() RA is a systemic autoimmune-mediated disease, and thus, RA patients can have both articular and extra-articular symptoms, which can significantly reduce the quality of life and increase medical expense. ![]() These pathologic cells cause synovitis and pannus formation in joints, and also induce an inflammatory response in extra-articular organs or tissues, such as the lungs, skin, eyes, or coronary arteries. Pathologic immune cells, such as helper T cells, cytotoxic T cells, autoantibody-producing plasma cells, and macrophages, are known to be involved in the pathogenesis of RA. Small joint synovitis is the most frequent symptom in patients with RA, and several synthetic and biologic disease-modifying antirheumatic drugs are used to control the inflammatory response in RA to prevent structural damage of the joints. Rheumatoid arthritis (RA) is an autoimmune-mediated inflammatory arthritis affecting 0.5–1% of the population. Therefore, the application of the ERS-RA method may be suitable for predicting subclinical atherosclerosis and CVD risk in RA patients. The ERS-RA method was highly correlated with the CAC score in RA patients. In multivariate linear regression analysis, ERS-RA (β = 10.01, 95% confidence interval 3.78–16.23) showed a positive association with the CAC score in RA patients. ERS-RA showed the highest correlation coefficient ( r = 0.430, P = 0.001). Correlation analysis and linear regression analysis between the CAC score and CVD risk score was performed. Computed tomography was used to determine the CAC score of each patient. ![]() Framingham risk score, Systemic Coronary Risk Evaluation (SCORE), Atherosclerotic Cardiovascular Disease (ASCVD) risk estimator plus, QRISK3, Expanded Risk Score in Rheumatoid Arthritis (ERS-RA), and Reynolds risk score. We recruited RA patients, and the 10-year CVD risk was assessed using various tools, viz. We estimated CVD risk using several methods and compared these with the CAC score to identify the most suitable CVD risk calculator in RA patients. Coronary artery calcium (CAC) score quantifies the severity of atherosclerosis. Cardiovascular diseases (CVDs) are the leading cause of death in patients with rheumatoid arthritis (RA).
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